Both THC and CBD interact synergistically to increase each other’s effect. CBD enhances THC properties of painkilling and anticancer while it also regulates the psychoactive effect caused by the THC and also mitigates the effects such as rapid heartbeat and anxiety.
Let’s explore some of the major differences between THC and CBD,
THE PSYCHOLOGICAL HIGH
THC, Tetrahydrocannabinol is the main psychoactive compound that is responsible for creating the high feeling that is associated with the marijuana use.
CBD, Cannabidiol does not directly bind with any of the receptor and is found to supress the psychoactive effect of the THC when both cannabinoids and tetrahydrocannabinol are consumed together.
THC, THC has a greater affinity towards the CB1 receptors so it binds with the CB1 receptors to activate them. THC imitates the effect of the anandamide which is responsible for enhancing the appetite and pleasure. Thus THC binds itself with the CB1 receptor and produces the high feeling that we get from the cannabis plant.
CBD, binds with the fatty acid binding proteins and travel through the cell membrane to interact with the other non-cannabinoid receptors of the body and is found to interact with the 5-HT1A, TRPV1, Adenosine, GPR55 and GABA receptors in different ways to cure of different diseases. CBD does not bind with the ECS receptors as THC does and is said to be the antagonists of the CB1 agonists and this is the reason why CBD’s effect opposes the effect of the THC.